Skip to main content
SpringerLink
Log in

Thin-target excitation functions and optimization of simultaneous production of NCA copper-64 and gallium-66,67 by deuteron induced nuclear reactions on a natural zinc target

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Copper-64 is a radionuclide suitable for labeling of a wide range of radiopharmaceuticals for PET imaging, as well as systemic or local radioimmunotherapy of tumors. Among the possible methods for cyclotron production of No Carrier Added (NCA) 64Cu (61Cu), we investigated the deuteron irradiation on natural Zn target, via (d,axn) and (d,2pxn) nuclear reactions. This paper reports the preliminary results about the experimental determination and theoretical calculation of thin-target excitation functions in the energy range up to 19 MeV for 61Cu, 64Cu, 66Ga, 67Ga, 65Zn and 69mZn. A fast selective radiochemical separation of NCA 64Cu from Zn target and Ga radionuclides, with quality control tests is described too.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

eferences

  1. E. Browne, R. B. Firestone, Table of Radioactive Isotopes, V. Shirley (Ed.), John Wiley & Sons, New York, USA, 1986, ISBN: 0-471-84909-X.

    Google Scholar 

  2. R. B. Firestone, C. M. Baglin, F. S. Y. Chu, Table of Isotopes, 8th ed., 1998, Update on CD-ROM, John Wiley & Sons, New York, USA, 1998, ISBN: 0-471-24699-9.

    Google Scholar 

  3. J. Inczedy, T. Lengyel, A. M. Ure, A. Gelencser, A. Hulanicki (Eds), Radioanalytical Methods, Chapter 16, in: IUPAC, Compendium of Analytical Nomenclature, Definitive Rules 1997, 3rd ed., Orange Book, UK, 2000, ISBN 0-86542-615-5.

  4. J. S. Lewis, M. J. Welch, Q. J. Nucl. Med., 45 (2001) 183.

    Google Scholar 

  5. S. Apelgot, E. Guillè, Anticancer Res., 9 (1989) 955.

    Google Scholar 

  6. P. J. Blower, J. S. Lewis, J. Zweit, Nucl. Med. Biol., 23 (1996) 957.

    Google Scholar 

  7. M. R. Lewis, M. Wang, L. A. Jones, D. B. Axworthy, M. J. Welch, C. J. Anderson, J. Label. Compd. Radiopharm., 42Suppl. 1 (1999) S252.

    Google Scholar 

  8. Z. Wang, Y. Guan, P. E. Fanwick, D. E. Bergstrom, M. A. Green, J. Label. Compd. Radiopharm., 42Suppl. 1 (1999) S246.

    Google Scholar 

  9. J. S. Lewis, J. Wang, C. J. Anderson, D. W. McCarthy, M. J. Welch, J. Label. Compd. Radiopharm., 42Suppl. 1 (1999) S753.

    Google Scholar 

  10. S. V. Smith, N. M. Di Bartolo, A. Sargeson, E. Hetherington, J. Label. Compd. Radiopharm., 42Suppl. 1 (1999) S841.

    Google Scholar 

  11. A. M. Wu, P. J. Yazaki, S. Tsai, K. Nguyen, A. L. Anderson, D. W. McCarthy, M. J. Welch, J. E. Shively, L. E. Williams, A. A. Raubitschek, J. Y. C. Wong, T. Toyokuni, M. E. Phelps, S. Gambhir, Proc. Natl. Acad. Sci. USA, 97 (2000) 8495.

    Google Scholar 

  12. N. M. Di Bartolo, S. V. Smith, A. Sargeson, J. Label. Compd. Radiopharm., 44 (2001) S691.

    Google Scholar 

  13. J. Yoo, D. Reichert, M. J. Welch, Label. Compd. Radiopharm., 44 (2001) S796.

    Google Scholar 

  14. G. Pfenning, H. Klewe-Nebenius, W. Seelmann-Eggebert, Karlsruher Nuklidkarte, 6 Auflage 1995, korrigierter Nachdruck 1998, KFK, Karlsruhe, Druckhaus Haberbeck GmbH, D-32791 Lage, Lippe, Germany, ISBN: 3-92-1879-18-3.

    Google Scholar 

  15. J. T. Van Elteren, K. J. Kroon, U. D. Woroniecka, J. J. M. De Goeij, Appl. Radiation Isotopes, 51 (1999) 15.

    Google Scholar 

  16. T. Matsuura, K. Sasaki, H. Shoji, J. Radioanal. Nucl. Chem., 134 (1989) 311.

    Google Scholar 

  17. A. P. Wolf, T. J. Tewson, M. J. Welch, J. Nucl. Med., 22 (1981) 392.

    Google Scholar 

  18. F. Szelecsenyi, G. Blessing, S. M. Qaim, Appl. Radiation Isotopes, 44 (1993) 575.

    Google Scholar 

  19. J. Zweit, A. M. Smith, S. Downey, H. L. Sharma, Appl. Radiation Isotopes, 42 (1991) 193.

    Google Scholar 

  20. K. Abbas, C. Birattari, M. Bonardi, F. Groppi, E. Menapace, D. Shaw, M. Severgnini, M. F. Stroosnijder, J. Label. Compd. Radiopharm., 44 (2001) S802.

    Google Scholar 

  21. M. Bonardi, C. Birattari, K. Abbas, F. Groppi, M. Severgnini, D. Shaw, E. Menapace, M. F. Stroosnijder, European J. Nucl. Med., 28 (2001) 1262.

    Google Scholar 

  22. D. C. Williams, J. W. Irvine, Phys. Rev., 130 (1963) 265.

    Google Scholar 

  23. C. Birattari, M. Bonardi, Ottimizzazione delle condizioni di irraggiamento per la produzione del radioisotopo 67Ga con il Ciclotrone di Milano, Report of National Institute of Nuclear Physics, INFN/TC-80/9, Frascati, Roma, Italy, 1980.

    Google Scholar 

  24. M. Bonardi, C. Birattari, J. Radioanal. Chem., 76 (1983) 311.

    Google Scholar 

  25. R. E. Weiner, M. L. Thakur, Radiochim. Acta, 70/71 (1995) 273.

    Google Scholar 

  26. J. F. Ziegler, J. P. Biersack, The Stopping and Range of Ions in Solids, Vol. I and Vols II-VI 1977, Pergamon Press, New York, 1985.

    Google Scholar 

  27. J. F. Ziegler, SRIM 2000 code. IBM-Research, Yorktown, New York, 2000.

    Google Scholar 

  28. M. Bonardi, C. Birattari, F. Groppi, E. Sabbioni, Appl. Radiation Isotopes, 57 (2002) 617.

    Google Scholar 

  29. IAEA-TECDOC-1211, Charged-particle Cross-Section Data-Base for Medical Radioisotope Production, Coordinated Research Project, 1995-1999, IAEA, Vienna, Austria, May 2001, Available online at: http://www-nds.iaea.org/medical/

  30. D. Basile, C. Birattari, M. Bonardi, L. Goetz, E. Sabbioni, A. Salomone, Intern. J. Appl. Radion Isotopes, 32 (1981) 403.

    Google Scholar 

  31. M. Bonardi, The contribution to nuclear data for medical radioisotope production from the Milan Cyclotron Laboratory, IAEA Consultant's Meeting on Nuclear Data Requirements for Medical Radioisotope Production, INDC(NDS)-195/GZ, IAEA, Vienna, Jan 1988, p. 98.

    Google Scholar 

  32. M. Bonardi, M. Gallorini, F. Groppi, L. Magon, A. Marchi, S. Saponaro, L. Ulrici, J. Radioanal. Nucl. Chem., 195 (1995) 227.

    Google Scholar 

  33. M. Gallorini, C. Birattari, M. Bonardi, L. Magon, E. Sabbioni, J. Radioanal. Nucl. Chem., 160 (1992) 493.

    Google Scholar 

  34. C. Birattari, M. Bonardi, F. Groppi, L. Gini, E. Menapace, Review of cyclotron production and quality control of high specific activity radionuclides for biomedical, biological, industrial and environmental applications at INFN-LASA. Proc. Intern. Congress on Cyclotrons and their Applications, Cyclotron 2001, East Lansing, Michigan, May 2001. American Institute of Physics, Melville, New York, USA.

    Google Scholar 

  35. L. Goetz, E. Sabbioni, E. Marafante, J. Edel-Rade, C. Birattari, M. Bonardi, J. Radioanal. Chem., 67 (1981) 183.

    Google Scholar 

  36. Enzo Menapace, ENEA, Bologna, Italy, private communication.

  37. R. D. Neirincks, Intern. J. Appl. Radiation Isotopes, 28 (1977) 802.

    Google Scholar 

  38. S. Mirzadeh, F. F. Knapp, Radiochim. Acta, 57 (1992) 193.

    Google Scholar 

  39. S. V. Smith, D. J. Waters, N. Di Bartolo, Radiochim. Acta, 75 (1996) 65.

    Google Scholar 

  40. X. Hou, U. Jacobsen, J. C. Jorgensen, Separation of no-carrier-added 64Cu from a proton irradiated 64Ni enriched nickel target, Appl. Radiation Isotopes, 2002, in press.

  41. J. Korkisch (Ed.), Ion Exchange Resins: Their Application to Inorganic Analytical Chemistry, CRC Press, Boca Raton, Florida, 1989.

    Google Scholar 

  42. M. Bonardi, F. Groppi, C. Birattari, D. Arginelli, J. Anal. Environ. Chem., 92 (2002) 795.

    Google Scholar 

  43. C. Birattari, M. Bonardi, S. De Crescenzo, G. Tosi, Fis. Med., 2 (1986) 119.

    Google Scholar 

  44. E. Sabbioni, L. Goetz, C. Birattari, M. Bonardi, Sci. Total Environ., 17 (1981) 257.

    Google Scholar 

  45. M. Gallorini, M. Bonardi, F. Groppi, S. Saponaro, J. Radioanal. Nucl. Chem., 193 (1995) 39.

    Google Scholar 

  46. S. R. Cherry, P. K. Marsden, R. J. Ott, M. A. Flower, S. Webb, J. W. Babich, Europ. J. Nucl. Med., 15 (1989) 694.

    Google Scholar 

  47. E. John, P. E. Fanwick, A. T. McKenzie, J. R. Stawell, M. A. Green, Nucl. Med. Biol., 16 (1989) 791.

    Google Scholar 

  48. D. W. McCarthy, R. E. Shefer, R. E. Klinkowstein, L. A. Bass, W. H. Margeneau, C. S. Cutler, C. J. Anderson, M. J. Welch, Nucl. Med. Biol., 24 (1997) 35.

    Google Scholar 

  49. A. B. Packard, J. F. Kranange, P. J. Day, S. T. Treves, Nucl. Med. Biol., 25 (1998) 531.

    Google Scholar 

  50. T. J. McCarthy, M. J. Welch, Semin. Nucl. Med., 28 (1998) 235.

    Google Scholar 

  51. D. J. Buchsbaum, B. E. Rogers, M. B. Khazaeli, M. S. Mayo, D. E. Milenic, S. V. S. Kashmiri, C. J. Anderson, L. L. Chappell, M. W. Brechbiel, D. T. Curiel, Clin. Cancer Res., 5 (1999) 3048.

    Google Scholar 

  52. J. S. Lewis, M. R. Lewis, P. D. Cutler, A. Srinivasan, M. A. Schmidt, S. W. Schwarz, M. M. Morris, J. P. Miller, C. J. Anderson, Clin. Cancer Res., 5 (1999) 3608.

    Google Scholar 

  53. C. S. Cutler, M. Wuest, C. J. Anderson, D. E. Reichert, Y. Z. Sun, A. E. Martell, M. J. Welch, Nucl. Med. Biol., 27 (2000) 375.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Accelerators and Applied Superconductivity Laboratory, LASA, Radiochemistry Laboratory, Universita' degli Studi and INFN, Via F.lli Cervi 201, I-20090, Segrate, Milano, Italy

    M. L. Bonardi, F. Groppi, C. Birattari, L. Gini, C. Mainardi & A. Ghioni

  2. Division for Advanced Physical Technologies, Via Don Fiammelli, 2, I-40128, Bologna, Italy

    E. Menapace

  3. Institute for Health and Consumer Protection, IHCP, JRC, Ispra, European Communities, Via E. Fermi 1, I-21020, Varese, Italy

    K. Abbas, U. Holzwarth & M. F. Stroosnijder

Authors
  1. M. L. Bonardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Groppi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Birattari
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Gini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Mainardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Ghioni
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. Menapace
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. K. Abbas
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. U. Holzwarth
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. F. Stroosnijder
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bonardi, M.L., Groppi, F., Birattari, C. et al. Thin-target excitation functions and optimization of simultaneous production of NCA copper-64 and gallium-66,67 by deuteron induced nuclear reactions on a natural zinc target. Journal of Radioanalytical and Nuclear Chemistry 257, 229–241 (2003). https://doi.org/10.1023/A:1024703022762

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1024703022762

Keywords

Search

Navigation